Scappettone works at the crossroads of scholarship, translation, and transmedia literary arts. Her books include Killing the Moonlight: Modernism in Venice and the poetry collections From Dame Quickly and The Republic of Exit 43. Her volume Locomotrix: Selected Poetry and Prose of Amelia Rosselli won the Academy of American Poets’s Raiziss/De Palchi Prize. She has exhibited her visual and performance poetry internationally. Her work has been supported by the Bogliasco Foundation, Djerassi, Stanford Humanities Center, and the American Academy in Rome. She teaches at the University of Chicago.